Used as a key intermediate in the synthesis of biologically active compounds, particularly in pharmaceuticals targeting central nervous system disorders. Its structure allows for selective functionalization, making it valuable in constructing complex molecules with high stereochemical control. Commonly employed in the development of protease inhibitors and receptor modulators due to its rigid framework and ability to mimic peptide bonds. Also utilized in medicinal chemistry for structure-activity relationship (SAR) studies, where the difluoropyrrolidine core enhances metabolic stability and bioavailability.