Sertindole is used in the treatment of schizophrenia to manage symptoms such as hallucinations, delusions, and disorganized thinking. It works by modulating certain neurotransmitters in the brain, primarily dopamine and serotonin. This action can help stabilize mood and improve cognitive function in patients with psychotic disorders. It may also be used off-label for other psychiatric conditions. However, its use requires careful monitoring due to potential cardiac side effects, including QT interval prolongation.