γ-Acetylenic GABA is primarily used in neuroscience research as a selective and irreversible inhibitor of the enzyme GABA transaminase. By inhibiting this enzyme, it increases the levels of GABA, the primary inhibitory neurotransmitter in the brain. This makes it a valuable tool for studying the role of GABA in various neurological processes and conditions, such as epilepsy, anxiety, and sleep disorders. Its application helps researchers understand the mechanisms of GABAergic signaling and develop potential therapeutic strategies for neurological diseases. Additionally, it is used in pharmacological studies to explore the effects of elevated GABA levels on neuronal activity and behavior.