TGN-020 is primarily utilized in research settings to study the function of aquaporin-4 (AQP4), a water channel protein found in the brain. It acts as a selective inhibitor of AQP4, making it a valuable tool for investigating the role of this protein in various physiological and pathological processes. Researchers use TGN-020 to explore its potential in conditions such as brain edema, neurodegenerative diseases, and stroke, where AQP4 is believed to play a significant role. Its application helps in understanding the mechanisms of water regulation in the central nervous system and in developing therapeutic strategies targeting AQP4-related disorders.