OM99-2 TFA is primarily used in biochemical research as a potent inhibitor of β-secretase (BACE1), an enzyme involved in the production of amyloid-beta peptides. Its application is significant in studies related to Alzheimer's disease, where it helps researchers understand the enzyme's role and explore potential therapeutic strategies. By inhibiting BACE1, it provides insights into reducing amyloid-beta plaque formation, a key hallmark of Alzheimer's pathology. Additionally, it serves as a valuable tool in drug discovery and development, aiding in the screening and optimization of new compounds targeting BACE1 for neurodegenerative disease treatment.