AZD-2858 is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3), an enzyme involved in multiple signaling pathways linked to inflammation, neurodegeneration, and metabolic regulation. Its primary application lies in research settings focused on understanding and potentially treating neurodegenerative diseases such as Alzheimer's disease, where GSK-3 overactivity is associated with the formation of neurofibrillary tangles. It has also been explored for its role in modulating Wnt signaling, which is important in stem cell regulation and tissue regeneration. Due to its anti-inflammatory and neuroprotective properties observed in preclinical models, AZD-2858 serves as a tool compound for studying central nervous system disorders and inflammatory conditions. It is not used clinically but supports drug discovery efforts targeting GSK-3-related pathologies.