This rat-specific variant of the β-Amyloid (1-42) peptide is widely used in neuroscience research, particularly in studies focused on Alzheimer's disease. It serves as a model for investigating the mechanisms of amyloid plaque formation, which is a hallmark of the disease. Due to sequence differences from the human form, the rat version is often employed in rodent models to study aggregation and toxicity with reduced human-like fibrillization. Researchers utilize it to explore the neurotoxic effects of amyloid-beta aggregation on neuronal cells and to test potential therapeutic compounds aimed at inhibiting or reversing amyloid-induced damage. Additionally, it is employed in animal models to mimic Alzheimer's pathology, helping to understand disease progression and evaluate the efficacy of experimental treatments. Its role in synaptic dysfunction and cognitive decline is also a key area of study.