DeMethyleneberberine, a derivative of the natural alkaloid berberine, is primarily researched for its potential therapeutic applications, particularly in the fields of metabolic and cardiovascular health. It has shown promise in improving insulin sensitivity and glucose metabolism, making it a candidate for managing type 2 diabetes and related metabolic disorders. Additionally, its anti-inflammatory and antioxidant properties are being explored for their role in protecting against cardiovascular diseases by reducing oxidative stress and inflammation in vascular tissues. Ongoing studies are investigating its potential in supporting liver health and detoxification processes, as well as in cancer therapy due to its ability to modulate cellular pathways involved in tumor growth and apoptosis.