Betulone is primarily used in pharmaceutical and cosmetic research due to its structural similarity to biologically active triterpenoids. It serves as an intermediate in the synthesis of derivatives with potential anti-inflammatory, antiviral, and anticancer properties. Researchers explore its role in modulating cellular pathways involved in oxidative stress and immune response. In skincare, betulone-based compounds are investigated for their ability to support skin barrier function and reduce irritation, making them candidates for dermatological formulations targeting sensitive or damaged skin. Its utility in semisynthetic pathways enhances the development of novel therapeutic agents derived from natural product scaffolds.