Gold nanostars are widely used in biomedical applications due to their unique optical properties and shape-dependent plasmonic behavior. Their star-like structure with sharp tips enhances localized surface plasmon resonance, making them highly effective in photothermal therapy, where they absorb near-infrared light and convert it into heat to destroy cancer cells selectively. They are also employed in biosensing and bioimaging, providing high-contrast imaging for early disease detection. Due to their surface geometry, gold nanostars offer multiple attachment points for targeting ligands, antibodies, or drugs, enabling targeted drug delivery and molecular sensing. Additionally, they serve as sensitive substrates in surface-enhanced Raman spectroscopy (SERS), allowing detection of biomolecules at very low concentrations. Their versatility supports advancements in diagnostics, therapeutics, and multimodal platforms combining imaging and treatment.