SHIN1 is primarily utilized in biochemical research as an inhibitor of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). NAMPT plays a critical role in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a vital coenzyme involved in cellular metabolism and energy production. By inhibiting NAMPT, SHIN1 is used to study the effects of reduced NAD+ levels on cellular processes, particularly in cancer research. It helps researchers understand the metabolic dependencies of cancer cells, as many tumors rely heavily on NAD+ for their rapid growth and survival. SHIN1 is also employed in studies exploring potential therapeutic strategies targeting NAMPT in various diseases, including cancer and inflammatory conditions. Its application extends to investigating the broader implications of NAD+ depletion in cellular aging, stress responses, and metabolic regulation.