VU0467154 is primarily used in research settings to study the role of specific receptors in the central nervous system. It acts as a selective antagonist for certain subtypes of muscarinic acetylcholine receptors, particularly the M4 subtype. This makes it a valuable tool for understanding the physiological and pathological functions of these receptors in conditions such as Parkinson's disease, schizophrenia, and substance use disorders. Researchers also utilize it to explore potential therapeutic applications, including the development of treatments for neurological and psychiatric disorders. Its selectivity allows for precise modulation of receptor activity, aiding in the investigation of receptor signaling pathways and their impact on behavior and cognition.