Zotarolimus, also known as ABT-578, is primarily used in the medical field, particularly in cardiovascular treatments. It is a key component in drug-eluting stents, which are small, mesh-like tubes inserted into narrowed or blocked arteries to keep them open. The compound works by inhibiting the proliferation of smooth muscle cells, which helps prevent restenosis, a common issue where the artery re-narrows after stent placement. This makes Zotarolimus highly effective in improving the long-term success of coronary artery interventions, reducing the need for repeat procedures. Its application has significantly advanced the treatment of coronary artery disease, offering patients better outcomes and enhanced quality of life.