Used in the treatment of osteoporosis, particularly in postmenopausal women at high risk of fractures. It helps increase bone mass by inhibiting bone resorption. Prevents skeletal-related events in patients with bone metastases from solid tumors, such as lung or breast cancer. This includes reducing the risk of fractures, spinal cord compression, or the need for radiation to bone. Treats bone loss in patients undergoing androgen deprivation therapy for prostate cancer and those on long-term glucocorticoid therapy. Used in the management of giant cell tumor of bone, a rare and locally aggressive tumor, by targeting RANKL-mediated osteoclast activation. Also applied in conditions with excessive bone destruction, such as hypercalcemia of malignancy and certain metabolic bone diseases.