Used in immunotherapy research for targeting Siglec-15, a protein involved in immune suppression within the tumor microenvironment. This antibody helps modulate immune cell activity, particularly macrophages and myeloid-derived suppressor cells, enhancing anti-tumor immune responses. Investigated for potential in cancer treatments, especially in solid tumors where Siglec-15 is overexpressed. Also serves as a tool in studying immune checkpoint pathways and bone metabolism due to Siglec-15's role in osteoclast regulation.