Used in targeted cancer therapies, particularly in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and other malignancies involving dysregulated Notch signaling. It functions by specifically binding to the NOTCH1 receptor, blocking its activation and downstream signaling pathways that promote tumor cell proliferation and survival. This antibody serves as a key component in the development of antibody-drug conjugates (ADCs) and bispecific antibodies, enabling precise delivery of cytotoxic agents or immune cell engagement. Its high specificity makes it valuable in diagnostic applications and as a research tool for studying Notch pathway biology in development and disease.