Used in immunotherapy research and development, particularly in oncology and autoimmune diseases. Binds to the NKG2D receptor on natural killer (NK) cells and certain T cells, modulating immune activation. Investigated for its ability to enhance anti-tumor immune responses by promoting NK cell-mediated cytotoxicity against cancer cells expressing NKG2D ligands. Also studied in autoimmune conditions to assess immune regulation by blocking overactive NKG2D signaling. Serves as a reference standard in antibody development and biosimilar characterization. Supports assay development, target validation, and pharmacokinetic studies in preclinical and clinical settings.