Used in targeted cancer therapy, particularly for melanoma and other solid tumors expressing MUC18/CD146. It blocks tumor cell migration, invasion, and angiogenesis by binding to CD146, a cell adhesion molecule overexpressed in cancer cells. This antibody is also being explored in autoimmune diseases due to its role in modulating immune cell trafficking. In research, it serves as a reference reagent for validating CD146 detection methods and evaluating therapeutic antibody candidates.