Used in research and diagnostic applications to detect MICA (MHC class I chain-related protein A) expression on cells, particularly in studies related to immune response, cancer, and transplant rejection. Binds specifically to MICA, enabling flow cytometry, immunohistochemistry, and ELISA assays. Supports development of immunotherapies by monitoring MICA shedding and NK cell activation. Also employed as a reference standard in antibody screening and assay validation.