Used in targeted cancer immunotherapies, particularly for tumors expressing the MAGE-A3 antigen such as melanoma, lung cancer, and synovial sarcoma. This reference antibody serves as a critical tool in the development and validation of diagnostic assays to detect MAGE-A3 expression in tumor tissues. It is also employed in the design of monoclonal antibody-based therapies and T-cell receptor engineering, including chimeric antigen receptor (CAR) T-cell development. Due to its high specificity, it supports quality control and batch consistency in biopharmaceutical manufacturing under patent-protected processes. Additionally, it is used in preclinical research to study antigen distribution, immune response mechanisms, and therapeutic efficacy.