Used in clinical research and therapeutic development for inflammatory diseases, particularly asthma, chronic obstructive pulmonary disease (COPD), atopic dermatitis, and allergic conditions. By neutralizing interleukin-33 (IL-33), a key mediator in type 2 inflammation, it helps reduce airway inflammation, mucus production, and hyperresponsiveness in respiratory diseases. It is also being studied in trials for eosinophilic esophagitis and other immune-mediated disorders. Its high specificity makes it valuable as a reference standard in bioassays and pharmacokinetic studies during drug development.