Used in the treatment of chronic inflammatory and autoimmune diseases, particularly asthma and atopic dermatitis, by blocking the IL-33 signaling pathway. It targets the ST2 receptor, preventing IL-33 from triggering immune cell activation and reducing inflammation. Investigated in clinical trials for pulmonary diseases and systemic sclerosis due to its ability to modulate type 2 immune responses. Also explored in transplant medicine to reduce graft-versus-host disease by suppressing T helper 2 cell activity.