Used in research and development for targeting interleukin-18 (IL-18), a pro-inflammatory cytokine involved in autoimmune and inflammatory diseases. It serves as a reference standard in immunoassays and bioassays to measure neutralization of IL-18 activity. Applied in studies related to lupus, rheumatoid arthritis, and other conditions where IL-18 signaling contributes to disease progression. Supports the development and validation of therapeutic antibodies by providing a benchmark for potency, specificity, and binding affinity. Also utilized in pharmacokinetic and pharmacodynamic studies during preclinical and clinical stages of drug development.