Used in research and diagnostic applications to detect histone H2B, a core component of chromatin. This antibody serves as a reference standard in immunoassays, particularly in studies related to epigenetics, DNA packaging, and nuclear structure. It is employed in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to monitor histone expression and modifications. Due to its specificity, it aids in the development and validation of assays targeting histone-related biomarkers, especially in autoimmune disease research and cancer studies where histone release and modification play a role. Its use is primarily restricted to laboratory settings for non-therapeutic purposes.