Anti-HGFR / c-Met Reference Antibody (onartuzumab)
Reagent
Code: #140143
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-20℃
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Used in targeted cancer therapy, particularly for tumors exhibiting dysregulated c-MET signaling pathway activity. Binds specifically to the extracellular domain of the c-MET receptor, blocking hepatocyte growth factor (HGF) interaction and inhibiting downstream signaling involved in tumor growth, invasion, and metastasis. Investigated in clinical trials for non-small cell lung cancer, gastric cancer, and other solid tumors, often in combination with other targeted agents or chemotherapy. Designed for intravenous administration as a humanized monoclonal antibody to minimize immunogenicity while enhancing therapeutic efficacy.
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