Used in research and diagnostic applications to detect and study GPR49 (also known as LGR5), a receptor expressed in stem cells of various tissues including the intestine, skin, and hair follicles. This antibody helps identify and isolate adult stem cells, particularly in cancer research where LGR5 is a marker for cancer stem cells in colorectal and other tumors. It is applied in immunohistochemistry, flow cytometry, and Western blotting to investigate stem cell behavior, tumor development, and regenerative processes. Also utilized in therapeutic development to target LGR5-positive cells in oncology and tissue regeneration studies.