Used in targeted cancer therapy to deliver therapeutic agents specifically to tumor sites by binding to fibronectin, a protein abundant in the extracellular matrix of tumors. This antibody is often conjugated with cytokines like TNF (tumor necrosis factor) to enhance localized anti-tumor immune responses while minimizing systemic toxicity. It is also employed in imaging applications to visualize tumor vasculature and monitor treatment efficacy. Its high specificity makes it valuable in preclinical research for studying tumor angiogenesis and stromal targeting strategies.