Used in research and diagnostic settings to specifically target and inhibit the Endothelin B receptor (ETBR), this antibody serves as a critical tool for studying endothelin signaling pathways involved in vascular regulation, neurobiology, and cancer progression. It is commonly applied in immunoassays, flow cytometry, and immunohistochemistry to detect ETBR expression in tissues and cells. Due to its high specificity, it is also employed as a reference standard in the development and validation of therapeutic antibodies targeting ETBR in conditions such as pulmonary arterial hypertension, melanoma, and chronic kidney disease.