Used in targeted cancer therapies, particularly for solid tumors and hematologic malignancies. Binds specifically to EphB4 receptor, which is overexpressed in certain cancers, enabling inhibition of tumor growth and angiogenesis. Investigated for use in antibody-drug conjugates (ADCs) to deliver cytotoxic agents directly to cancer cells. Also employed in diagnostic imaging to detect EphB4-positive tumors. Supports research in tumor microenvironment and receptor signaling pathways.