Used in research and therapeutic development targeting the CXCR4 chemokine receptor, which plays a key role in cancer metastasis, stem cell trafficking, and HIV infection. This reference antibody is instrumental in blocking CXCR4 signaling, enabling studies on cell migration, tumor progression, and hematopoietic stem cell mobilization. It serves as a benchmark in immunoassays and flow cytometry for detecting CXCR4 expression. Due to its well-characterized binding properties, it supports the development of new anti-cancer and anti-inflammatory drugs, particularly in leukemia and solid tumor research. It is also used in validating CXCR4-targeted imaging agents and therapeutic antibodies.