Used in research and therapeutic development targeting inflammatory diseases and certain cancers. Binds specifically to the CSF2RB (CD131) subunit of the GM-CSF receptor, modulating immune cell signaling. Investigated for its potential in treating autoimmune conditions such as rheumatoid arthritis and multiple sclerosis by dampening pro-inflammatory responses mediated by GM-CSF. Also explored in oncology for its role in disrupting tumor-associated macrophage activity and myeloid-derived suppressor cells that support tumor growth. Serves as a reference reagent in antibody development and receptor binding assays.