Used in the treatment of immune-mediated inflammatory conditions and respiratory disorders involving excessive inflammation, particularly in diseases like severe COVID-19 and chronic inflammatory lung diseases. It neutralizes granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine driving hyperinflammation and immune cell activation. By blocking GM-CSF, it helps reduce cytokine release syndrome, lung inflammation, and tissue damage, improving oxygenation and clinical outcomes. Investigated in clinical trials for its ability to prevent progression to mechanical ventilation in acute respiratory distress syndrome (ARDS). Also explored in autoimmune conditions such as rheumatoid arthritis and multiple sclerosis where GM-CSF contributes to disease pathology. Its targeted mechanism preserves broader immune function while dampening pathological inflammation.