Used in targeted cancer therapy, particularly for tumors dependent on tumor-associated macrophages. Blocks the CSF1 receptor, inhibiting macrophage survival and recruitment, which can reduce tumor growth and metastasis. Investigated in clinical trials for tenosynovial giant cell tumor, diffuse-type giant cell tumor, and certain solid tumors like pancreatic and breast cancer. Also explored for use in combination with other immunotherapies to enhance anti-tumor immune responses.