Used in immunological research and therapeutic development targeting plasmacytoid dendritic cells (pDCs). Specifically binds to CLEC4C (BDCA-2), a receptor found on pDCs, enabling modulation of interferon-alpha production, which plays a key role in autoimmune diseases such as systemic lupus erythematosus (SLE). This antibody is utilized in assays to deplete or inhibit pDC activity, making it valuable in studying immune regulation and developing treatments for chronic inflammatory and autoimmune conditions. Its application extends to functional studies in flow cytometry, immunohistochemistry, and in vivo models to track or block pDC responses.