Used in the treatment of autoimmune diseases and inflammatory conditions by targeting and depleting CD83-expressing dendritic cells, which play a key role in activating immune responses. This antibody helps modulate the immune system, reducing the pathological immune activation seen in diseases such as multiple sclerosis, rheumatoid arthritis, and lupus. It is also being explored in transplant medicine to prevent graft-versus-host disease and to promote tolerance to transplanted organs. Its high specificity allows for targeted therapy with potentially fewer systemic side effects compared to broad immunosuppressants.

Additionally, this antibody is studied for its role in regulating B cells involved in antigen presentation and immune activation.

In cancer research, the anti-CD83 antibody shows potential in enhancing immunotherapy by modulating the tumor microenvironment, which may help reduce cancer cell metastasis and improve response to treatments.