Used in the treatment of neovascular age-related macular degeneration (nAMD) and other ocular diseases involving abnormal blood vessel growth. It functions by inhibiting angiopoietin-2 (ANGPT2), a key mediator in vascular instability and inflammation. By blocking ANGPT2, it helps reduce vascular leakage, suppress pathological angiogenesis, and improve vascular integrity in the retina. Often explored in combination with VEGF inhibitors to enhance therapeutic efficacy in patients with diabetic macular edema and retinal vein occlusion. Also under investigation for potential use in cancer therapy due to ANGPT2's role in tumor angiogenesis and immune modulation.