Used in targeted cancer therapies, particularly in melanoma and certain solid tumors where ABCB5-expressing cancer stem cells contribute to tumor growth, drug resistance, and recurrence. This antibody enables selective targeting and elimination of these resistant cell populations, enhancing the efficacy of chemotherapy and immunotherapy. It is also employed in diagnostic and imaging applications to detect ABCB5-positive cells, aiding in patient stratification and treatment monitoring. Additionally, research explores its role in modulating multidrug resistance by inhibiting ABCB5 transporter activity, potentially reversing resistance to conventional anticancer drugs.