Used in research and therapeutic development targeting inflammatory and autoimmune diseases. Specifically binds to the C5a receptor (C5aR1) to block the activity of complement component C5a, a potent pro-inflammatory mediator. This inhibition helps reduce inflammation in conditions such as rheumatoid arthritis, sepsis, and inflammatory bowel disease. Also employed in experimental models of neuroinflammation, ischemia-reperfusion injury, and chronic obstructive pulmonary disease (COPD) to study the role of the complement system. Its high specificity makes it a valuable tool for flow cytometry, immunohistochemistry, and in vivo neutralization studies.