AR-C155858 is primarily used in research settings as a potent and selective inhibitor of monocarboxylate transporters (MCTs), particularly MCT1 and MCT2. These transporters play a crucial role in the metabolism of cancer cells by facilitating the uptake of lactate and other monocarboxylates, which are essential for their energy production. By inhibiting MCT1, AR-C155858 disrupts the lactate shuttle mechanism, potentially starving cancer cells of their energy source and inhibiting tumor growth. This makes it a valuable tool in studying cancer metabolism and exploring potential therapeutic strategies targeting metabolic pathways in oncology. Additionally, it is used in preclinical studies to understand the role of MCTs in other physiological and pathological processes, such as immune regulation and neurological disorders.