Clorgiline hydrochloride is primarily used in biochemical research as a selective and irreversible inhibitor of monoamine oxidase A (MAO-A). It is employed to study the role of MAO-A in neurotransmitter regulation and its impact on neurological and psychiatric conditions. Researchers utilize it to explore the mechanisms of depression, anxiety, and other mood disorders, as MAO-A is involved in the breakdown of serotonin, norepinephrine, and dopamine. Additionally, it helps in understanding the enzyme's role in neurodegenerative diseases like Parkinson's and Alzheimer's. Its application extends to pharmacological studies aimed at developing MAO-A-targeting drugs for therapeutic purposes.