RS-1 is widely used in genetic engineering and gene editing research, particularly in enhancing the efficiency of homology-directed repair (HDR) during CRISPR-Cas9 genome editing. It increases the precision of targeted gene modifications by promoting the insertion or correction of DNA sequences using a donor template, making it valuable for creating disease models, gene therapies, and functional genomics studies. RS-1 is especially useful in applications requiring high specificity, such as correcting point mutations or inserting reporter genes, where minimizing off-target effects and maximizing accurate repair outcomes are critical. Its role in improving HDR rates makes it a key tool in stem cell engineering and therapeutic development.