IM-12 is a small molecule inhibitor of the canonical Wnt/β-catenin signaling pathway, primarily acting by promoting the degradation of β-catenin and suppressing downstream gene transcription. It is widely used in biomedical research, especially for cancer studies, where it inhibits proliferation and induces apoptosis in various cancer cell lines, including those resistant to standard therapies. Additionally, IM-12 is explored in applications for inflammatory and autoimmune diseases due to its ability to modulate immune responses, reduce cytokine production, and balance immune system function. Its role in stem cell biology and regenerative medicine further highlights its value as a research tool.