Diethyl aminomalonate hydrochloride is widely used in organic synthesis as a versatile building block for the preparation of various heterocyclic compounds. It serves as a key intermediate in the synthesis of amino acids and peptides, particularly in the production of unnatural amino acids for pharmaceutical research. The compound is also employed in the development of bioactive molecules and drug candidates, owing to its ability to introduce both amino and ester functional groups into target structures. Additionally, it finds application in the synthesis of chiral compounds, where its reactivity and stability make it a valuable reagent in asymmetric synthesis. Its role in the preparation of complex organic molecules highlights its importance in medicinal chemistry and material science.