LY-367385 hydrochloride is primarily used in research settings to study its effects on neurotransmitter systems, particularly as a selective antagonist for metabotropic glutamate receptors (mGluR1). It helps in understanding the role of these receptors in various neurological processes and disorders, such as anxiety, depression, and neurodegenerative diseases. Researchers utilize it to explore potential therapeutic targets and mechanisms in the central nervous system. Its application is crucial in advancing knowledge of glutamate signaling pathways and their implications in brain function and disease.