ONO-RS-082 is primarily used in research settings as a selective antagonist for group II metabotropic glutamate receptors (mGluRs). Its application is significant in neuroscience studies, particularly in understanding the role of these receptors in synaptic transmission and plasticity. Researchers utilize it to investigate the mechanisms underlying neurological disorders such as anxiety, depression, and schizophrenia. By blocking group II mGluRs, ONO-RS-082 helps elucidate the pathways involved in these conditions, aiding in the development of potential therapeutic strategies. Additionally, it is employed in electrophysiological and behavioral experiments to study the effects of glutamate receptor modulation on brain function and behavior.