SHIP2-IN-1 is a selective inhibitor of SHIP2 (Src homology 2 domain-containing inositol 5-phosphatase 2), an enzyme involved in the regulation of the PI3K signaling pathway. It is primarily used in research to study insulin signaling and glucose homeostasis. By inhibiting SHIP2, this compound enhances Akt phosphorylation, leading to improved insulin sensitivity in cellular models. It has shown potential in the investigation of type 2 diabetes and metabolic disorders. Additionally, SHIP2-IN-1 is used to explore cancer cell proliferation and survival, as the PI3K pathway is often dysregulated in various cancers. Its application remains confined to preclinical research, aiding in target validation and pathway analysis.