SR 8278 is primarily used in scientific research as a selective inverse agonist of the REV-ERB nuclear receptors (REV-ERBα and REV-ERBβ). It is employed to modulate circadian rhythm pathways, making it a valuable tool in studies related to biological clocks, sleep disorders, and metabolic regulation. Researchers also utilize SR 8278 to investigate the role of REV-ERB in lipid and glucose metabolism, inflammation, and neurobehavioral functions. Due to its ability to disrupt REV-ERB activity, it helps in understanding the receptor’s influence on gene expression involved in these processes. Its application remains confined to preclinical research and is not used in clinical or therapeutic settings.