2-((6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide
98%
Reagent
Code: #232188
CAS Number
1983196-25-3
blur_circular Chemical Specifications
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Molecular Information
Weight
491.99 g/mol
Formula
C₂₅H₂₂ClN₅O₂S
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Storage & Handling
Storage
Room temperature
description Product Description
Used in pharmaceutical research as a potent and selective inhibitor of the enzyme diacylglycerol O-acyltransferase 1 (DGAT-1), which plays a key role in triglyceride synthesis. This compound is investigated for its potential in treating metabolic disorders such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD) by modulating fat absorption and storage. It has shown efficacy in preclinical models in reducing body weight gain and improving insulin sensitivity. Its structure allows for high binding affinity and selectivity, making it a valuable tool compound in metabolic disease drug development.
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