PHTPP is primarily used as a selective antagonist for the estrogen-related receptor gamma (ERRγ). It plays a significant role in research settings, particularly in studies related to cellular metabolism, mitochondrial function, and energy homeostasis. Due to its ability to modulate ERRγ activity, PHTPP is employed in investigating metabolic diseases, cancer metabolism, and cardiac function. It helps scientists understand the signaling pathways involved in energy regulation and has potential implications in developing therapies targeting metabolic disorders and certain cancers. Its application remains largely confined to laboratory and preclinical research.