Used primarily in research settings as a potent and selective inverse agonist of the RORα and RORγ nuclear receptors. It helps modulate circadian rhythm pathways and is employed to study the role of ROR receptors in metabolic regulation, inflammation, and immune function. Due to its ability to suppress RORγ-mediated transcription, it has been investigated for potential therapeutic applications in autoimmune diseases and cancers linked to RORγ overexpression. Commonly applied in cellular and animal models to probe the biological functions of the retinoic acid receptor-related orphan receptors.